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When estimated from ECG recordings, Citalopram ( Celexa ) and

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probably via a carrier mediated

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transport mechanism. Comparative animal studies on cardiovascular toxicity of tri- and tetracyclic antidepressants and Citalopram ( Celexa ); relation to drug plasma levels.The aim of the present study was to compare cardiovascular and/or cardiotoxic effects of eight anti-depressants (imipramine, chlorimipramine, Amitriptyline ( Elavil ), nortriptyline

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, doxepin,

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maprotiline, mianserin and Citalopram ( Celexa )) in anaesthetized cats after oral dosing and in conscious rabbits after intravenous infusion. Anterior

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segment area under curve values were 53.70 ( /-35.58), 139.85 ( /-9.43) and 291.05 ( /-88.13) min x micromoles/L respectively while the mean residence time values were 46.47 ( /-24.94), 76.30 ( /-7.24) and 188.39 ( /-80.73) min respectively. Vitreous levels of the prodrugs

famciclovir

were

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not measurable. In the cats drug plasma levels were determined as well. The plasma bioavailability for Acyclovir / Aciclovir, Valacyclovir ( Valtrex ) and val-Valacyclovir ( Valtrex ) were similar with area under curve values being 896.24

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( /-143.58), 776.54 ( /-197.52), 824.69 ( /-217.43) min x micromoles/L respectively. To investigate the ocular penetration of Acyclovir / Aciclovir and its prodrugs following systemic administration and to elucidate the mechanism of penetration. The cardiovascular effects seen in the cats were with few exceptions identical for all the drugs tested but not seen at the same dose (concentration). From comparisons of the safety margins it is concluded that except for Citalopram ( Celexa ) and mianserin (safety margins

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80 and 18 respectively in cats and greater than 15 in rabbits) all the other drugs tested (safety margins less than or equal to 9) have a cardiotoxic potential. The probability that cardiovascular side effects may occur is less pronounced for Citalopram ( Celexa ) (safety margins 10-32) than

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for all the other drugs tested (safety margins ranging from 0.1 to less than 5).. Safety margins were defined as minimal doses or plasma levels when ECG changes (conduction or rhythm) or cardiovascular effects ( /- 10% change of initial value in a series of parameters) occurred in experimental animals divided by maximal therapeutic dose or mean plasma levels in patients. Ocular penetration of Acyclovir / Aciclovir and its peptide prodrugs Valacyclovir ( Valtrex ) and val-Valacyclovir ( Valtrex ) following systemic administration in rabbits. Aqueous and vitreous humor samples were obtained utilizing ocular microdialysis and blood samples were obtained from the mid ear vein using a cannula.